Potentiometric titration systems can use a copper ISE for the titration of nickel by adding a small amount of copper EDTA (CuEDTA)to the sample. EDTA is then used as a titrant to react with free copper ions displaced by nickel in the solution. When this happens, the activity of the copper ion drastically decreases, which is detected by the cupric ISE. The use of a titration system allows for a precision measurement that can be automated for multiple measurements.
The copper ISE is available as either a single half-cell or combination design that is complete with a reference cell.